口腔癌和潜在恶性疾病中的组织血型抗原。

Histo-Blood Group Antigens in Oral Cancer and Potentially Malignant Disorders.

机构信息

Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India.

Private Practitioner, Hyderabad. India.

出版信息

Asian Pac J Cancer Prev. 2020 Apr 1;21(4):1163-1166. doi: 10.31557/APJCP.2020.21.4.1163.

DOI:10.31557/APJCP.2020.21.4.1163

PMID:32334486

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7445960/

Abstract

BACKGROUND

Early detection of oral cancer is of critical importance because survival rates markedly improve when oral lesions are identified at an early stage. Aim of the present study is to investigate the expression of ABO (H) antigens in tissue specimens of oral cancer and potentially malignant disorders and to determine the role of ABO (H) antigens in tumour staging.

MATERIALS AND METHODS

A prospective study was conducted on 60 cases of oral cancer and potentially malignant diseases. Specific red cell adherence test (SRCA-test) was used for studying A, B and O (H) antigens in tissue specimens and iso-antigenicity of epithelium was graded according to degree of adherence of indicator red blood cells.

RESULTS

Among OSMF group, grade II adherence was seen in 53.3% cases, grade III in 33.3% cases, grade IV in 13.3% cases. In leukoplakia group, grade II adherence was seen in 26.7% cases, grade III adherence in 53.3% cases, grade IV adherence in 20% cases. Within the leukoplakia group, cases with dysplasia showed decreased adherence, compared with cases without dysplasia. Oral cancer group, negative adherence was seen in 13.3% cases, grade I adherence in 46.7% cases, grade II in 40% cases. In oral cancer group, antigen reactivity was less in poorly and moderately differentiated carcinoma, compared to well differentiated carcinoma.

CONCLUSIONS

Antigen adherence and degree of loss of ABO (H) antigens in tissue specimens can be used for staging of the tumour.

摘要

背景

早期发现口腔癌至关重要，因为在早期发现口腔病变时，生存率显著提高。本研究旨在探讨 ABO（H）抗原在口腔癌和潜在恶性疾病组织标本中的表达，并确定 ABO（H）抗原在肿瘤分期中的作用。

材料和方法

对 60 例口腔癌和潜在恶性疾病患者进行了前瞻性研究。采用特异性红细胞粘附试验（SRCA 试验）研究组织标本中的 A、B 和 O（H）抗原，并根据指示性红细胞粘附程度对上皮同种抗原性进行分级。

结果

在 OSMF 组中，II 级粘附见于 53.3%的病例，III 级粘附见于 33.3%的病例，IV 级粘附见于 13.3%的病例。在白斑病组中，II 级粘附见于 26.7%的病例，III 级粘附见于 53.3%的病例，IV 级粘附见于 20%的病例。在白斑病组中，伴有发育不良的病例与无发育不良的病例相比，粘附性降低。口腔癌组中，13.3%的病例呈阴性粘附，46.7%的病例呈 I 级粘附，40%的病例呈 II 级粘附。在口腔癌组中，与高分化癌相比，低分化和中分化癌的抗原反应性较低。