Uvnäs B, Uvnäs-Wallensten K, Nilsson G
Acta Physiol Scand. 1975 Jun;94(2):167-76. doi: 10.1111/j.1748-1716.1975.tb05876.x.
Gastrin released by electrical vagal stimulation was measured in the portal blood of eviscerated cats. Blood flow was recorded by a drop chamber technique and the total gastrin output calculated. Basal peripheral gastrin levels averaged 65 pg/ml and basal portal levels 225 pg/ml. On unilateral vagal stimulation with frequencies above 3-4 Hz gastrin release rapidly increased, reaching a peak within 5-10 min. In spite of continued stimulation and independent of frequency, the gastrin levels declined and returned to basal values after a total of 2-3 000 stimuli. A new maximal response could be induced first after a recovery period of 15-30 min. In the same cat stimulation of either the left or the right vagus released equal maximal amounts of gastrin (average 32 000 pg). The maximal gastrin output on vagal stimulation corresponds to less than 1% of the total content of antral gastrin determined with radioimmunoassay.
通过电刺激迷走神经，在摘除内脏的猫的门静脉血中测量胃泌素的释放量。采用滴注室技术记录血流量，并计算胃泌素的总输出量。外周基础胃泌素水平平均为65 pg/ml，门静脉基础水平为225 pg/ml。在频率高于3 - 4 Hz的单侧迷走神经刺激下，胃泌素释放迅速增加，在5 - 10分钟内达到峰值。尽管持续刺激且与频率无关，但在总共2000 - 3000次刺激后，胃泌素水平下降并恢复到基础值。在15 - 30分钟的恢复期后，首先可以诱导出新的最大反应。在同一只猫中，刺激左侧或右侧迷走神经释放的胃泌素最大量相等（平均为32000 pg）。迷走神经刺激时的最大胃泌素输出量不到用放射免疫测定法测定的胃窦胃泌素总量的1%。
