Rajendran P R, Thompson R E, Reich S G
Boston University School of Medicine, Boston, MA, USA.
Neurology. 2001 Sep 11;57(5):790-4. doi: 10.1212/wnl.57.5.790.
To determine the prevalence and spectrum of use of alternative therapy (AT) by patients with PD and to determine whether use of AT correlates with demographic, social, or disease-specific characteristics.
The authors administered a structured questionnaire, by interview, regarding the use of AT to 201 patients with PD. Demographic, social, and disease-specific characteristics were recorded for all patients.
Eighty-one patients (40%) used at least one AT. Vitamins and herbs, massage, and acupuncture were most common. Users of AT were younger (p = 0.0021) and had a younger age at onset of PD (p = 0.0011) than nonusers of AT. There was no correlation with sex or race. Patients who used AT had a higher income (p = 0.038) and education level (p = 0.006) than did nonusers of AT. There was no association between the use of AT and the Hoehn and Yahr score, duration of PD, duration of treatment with levodopa, surgery for PD, and presence of fluctuations.
The use of AT is common in patients with PD. The age at onset of PD is the most potent predictor of AT use. There is no association between the use of AT and the severity of PD. The widespread and largely unexamined use of AT for PD requires more attention. This should be directed at testing their safety and efficacy and improving physician and patient knowledge about the potential benefits, costs, limitations, and risks of AT.
确定帕金森病（PD）患者使用替代疗法（AT）的患病率及使用范围，并确定AT的使用是否与人口统计学、社会或疾病特异性特征相关。
作者通过访谈对201例PD患者进行了关于AT使用情况的结构化问卷调查。记录了所有患者的人口统计学、社会和疾病特异性特征。
81例患者（40%）至少使用过一种AT。维生素和草药、按摩及针灸最为常见。与未使用AT的患者相比，使用AT的患者更年轻（p = 0.0021），且PD发病年龄更小（p = 0.0011）。与性别或种族无关。使用AT的患者比未使用AT的患者收入更高（p = 0.038）、教育水平更高（p = 0.006）。AT的使用与Hoehn和Yahr评分、PD病程、左旋多巴治疗时长、PD手术及症状波动情况之间无关联。
AT在PD患者中使用普遍。PD发病年龄是AT使用的最有力预测因素。AT的使用与PD严重程度无关。AT在PD治疗中的广泛且大多未经检验的使用需要更多关注。这应针对测试其安全性和有效性，并提高医生和患者关于AT潜在益处、成本、局限性及风险的知识。
