Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
College of Medicine, China Medical University, Taichung, Taiwan.
Adv Exp Med Biol. 2023;1411:435-458. doi: 10.1007/978-981-19-7376-5_19.
In this chapter, we conducted a systemic literature review for the anti-inflammatory effects of Traditional Chinese Medicine (TCM) applying molecular mechanisms focusing on the neuroinflammation and gut-brain axis in three neuropsychiatric disorders: major depressive disorder, Alzheimer's disease, and Parkinson's disease. We demonstrated the anti-inflammation or immunomodulation effects of TCM, including acupuncture, from basic and clinical research, including cellular and molecular approaches. In conclusion, inflammation plays a critical role in the neuropsychopathological process. At the same time, anti-inflammation seems to be the common biological pathway for the effects of TCM and acupuncture in depression, Alzheimer's disease, and Parkinson's disease.
在本章中,我们通过系统的文献回顾,应用分子机制研究了中医药(TCM)在三种神经精神疾病(即重度抑郁症、阿尔茨海默病和帕金森病)中的抗炎作用,重点关注神经炎症和肠脑轴。我们展示了 TCM 的抗炎或免疫调节作用,包括针灸,这是基于基础和临床研究的,包括细胞和分子方法。总之,炎症在神经精神病理过程中起着关键作用。同时,抗炎似乎是 TCM 和针灸在抑郁症、阿尔茨海默病和帕金森病中产生作用的共同生物学途径。