维生素D受体基因多态性与结直肠腺瘤风险（美国）

Vitamin D receptor polymorphisms and risk of colorectal adenomas (United States).

作者信息

Ingles S A, Wang J, Coetzee G A, Lee E R, Frankl H D, Haile R W

机构信息

Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA.

出版信息

Cancer Causes Control. 2001 Sep;12(7):607-14. doi: 10.1023/a:1011292002475.

DOI:10.1023/a:1011292002475

PMID:11552708

Abstract

OBJECTIVE

The purpose of this study was to determine whether vitamin D receptor (VDR) gene polymorphisms influence risk of colorectal adenoma.

METHODS

Polymorphisms in the 5' and 3' ends of the VDR gene were genotyped for 373 colorectal adenoma cases and 394 controls.

RESULTS

Overall, there was no significant association between the 5' (FokI) or the 3' (BsmI) polymorphisms and adenoma risk. However, risk of large (>1 cm) adenomas decreased with increasing copies of the FokI f allele (p = 0.04). Compared to the FF genotype, odds ratios for the Ff and ff genotypes were 0.79 (95% CI 0.44-1.41) and 0.32 (95% CI 0.11-0.91), respectively. FokI genotype was more strongly related to large adenoma risk among subjects with low dietary calcium intake (ORFf=0.48; 95% CI 0.17-1.3; ORff=0.21: 95% CI 0.04-1.3), low dietary vitamin D intake (ORFf=0.25; 95% CI 0.09-0.69; ORff= 0.22; 95% CI 0.04-1.2), or dark skin color (ORFf=0.66; 95% CI 0.27-1.6; ORff=0.10; 95% CI 0.01-1.0).

CONCLUSION

These results suggest that VDR FokI genotype influences development of colorectal adenomas. and that the effect may be modified by calcium and vitamin D status.

摘要

目的

本研究旨在确定维生素D受体（VDR）基因多态性是否会影响结直肠腺瘤的发病风险。

方法

对373例结直肠腺瘤病例和394例对照进行VDR基因5'端和3'端多态性的基因分型。

结果

总体而言，5'端（FokI）或3'端（BsmI）多态性与腺瘤发病风险之间无显著关联。然而，随着FokI f等位基因拷贝数增加，大（>1 cm）腺瘤的发病风险降低（p = 0.04）。与FF基因型相比，Ff和ff基因型的优势比分别为0.79（95%可信区间0.44 - 1.41）和0.32（95%可信区间0.11 - 0.91）。在饮食钙摄入量低（ORFf = 0.48；95%可信区间0.17 - 1.3；ORff = 0.21：95%可信区间0.04 - 1.3）、饮食维生素D摄入量低（ORFf = 0.25；95%可信区间0.09 - 0.69；ORff = 0.22；95%可信区间0.04 - 1.2）或肤色较深的受试者中，FokI基因型与大腺瘤发病风险的相关性更强（ORFf = 0.66；95%可信区间0.27 - 1.6；ORff = 0.10；95%可信区间0.01 - 1.0）。