Ortiz J J, Ayoub A, Gargala G, Chegne N L, Favennec L
Cajamarca General Hospital, Cajamarca, Peru.
Aliment Pharmacol Ther. 2001 Sep;15(9):1409-15. doi: 10.1046/j.1365-2036.2001.01066.x.
Enteric infection by Giardia intestinalis is a common cause of diarrhoea world-wide and a significant cause of morbidity in children.
To compare the efficacy and safety of nitazoxanide and metronidazole in the treatment of diarrhoea caused by G. intestinalis in children.
A total of 110 children presenting with diarrhoea caused by G. intestinalis were randomized to treatment with either a 3-day course of nitazoxanide (100 mg b.d., age range 2-3 years; 200 mg b.d., age range 4-11 years) or a 5-day course of metronidazole (125 mg b.d., age range 2-5 years; 250 mg b.d., age range 6-11 years). The patients were followed-up for a determination of clinical response 7 days after the initiation of treatment, and two subsequent stool samples were collected for parasitological examination.
Diarrhoea had resolved in 47 children out of 55 (85%) in the nitazoxanide treatment group before the day 7 follow-up visit, compared to 44 out of 55 (80%) for metronidazole. Diarrhoea resolved within 4 days in most cases. Only mild, transient adverse events were reported.
A 3-day course of nitazoxanide suspension is as efficacious as a standard 5-day course of metronidazole suspension in treating giardiasis in children.
肠道贾第虫感染是全球腹泻的常见病因，也是儿童发病的重要原因。
比较硝唑尼特和甲硝唑治疗儿童肠道贾第虫引起的腹泻的疗效和安全性。
总共110名患有肠道贾第虫引起的腹泻的儿童被随机分为两组，一组接受为期3天的硝唑尼特治疗（2至3岁儿童每日两次，每次100毫克；4至11岁儿童每日两次，每次200毫克），另一组接受为期5天的甲硝唑治疗（2至5岁儿童每日两次，每次125毫克；6至11岁儿童每日两次，每次250毫克）。在开始治疗7天后对患者进行随访以确定临床反应，并收集随后的两份粪便样本进行寄生虫学检查。
在第7天随访前，硝唑尼特治疗组的55名儿童中有47名（85%）腹泻已缓解，甲硝唑组的55名儿童中有44名（80%）腹泻已缓解。大多数病例的腹泻在4天内缓解。仅报告了轻度、短暂的不良事件。
硝唑尼特混悬液3天疗程在治疗儿童贾第虫病方面与甲硝唑混悬液标准5天疗程一样有效。
