Gazder A J, Banerjee M
Drugs. 1978;15 Suppl 1:30-2. doi: 10.2165/00003495-197800151-00007.
In random order, a single dose of either tinidazole or metronidazole, calculated as 50mg/kg body weight, was given to 100 children with symptomatic giardiasis. Follow-up was done for 16 days and consisted of 4 clinical, parasitological and biochemical assessments at intervals of 4 days. The actual mean dose of the drugs received by the patients was 55.5 mg/kg of tinidazole and 52.0mg/kg of metronidazole. Success, i.e. parasitic clearance and symptomatic relief, was achieved in 80% of patients given tinidazole as opposed to 36% of patients given metronidazole (p less than 0.01). Moreover, control of diarrhoea and negative stool conversion for G. lamblia occurred earlier with tinidazole than with metronidazole (p less than 0.01). The incidence of gastrointestinal side-effects was 12% for tinidazole and 4% for metronidazole. Neither drug caused any abnormality of the blood count, blood urea, urine analysis or liver function tests.
将100名有症状的贾第虫病患儿随机分为两组，分别给予单剂量的替硝唑或甲硝唑，剂量按体重50mg/kg计算。随访16天，期间每隔4天进行4次临床、寄生虫学和生化评估。患者实际接受的药物平均剂量为替硝唑55.5mg/kg，甲硝唑52.0mg/kg。接受替硝唑治疗的患者中80%取得成功，即寄生虫清除且症状缓解，而接受甲硝唑治疗的患者中这一比例为36%（p<0.01）。此外，替硝唑比甲硝唑更早控制腹泻且使粪便中蓝氏贾第鞭毛虫转阴（p<0.01）。替硝唑胃肠道副作用发生率为12%，甲硝唑为4%。两种药物均未引起血常规、血尿素、尿液分析或肝功能检查的任何异常。
