Kalis J M, Quie P G, Balfour H H
Am J Epidemiol. 1975 Jun;101(6):527-31. doi: 10.1093/oxfordjournals.aje.a112124.
Measles (rubeola) immunity among 479 elementary schoolchildren from suburban Minneapolis was serologically surveyed in December 1971. Of the 479 children, 25 (5.2%) had hemagglutination-inhibition (HI) titers less than 2. These children were considered susceptible to measles. For the 233 immunized children with no measles history, 13 (5.6%) had rubeola HI titers less than 2 while 5 (5.1%) of the 98 youngsters with a history of clinical measles had rubeola HI titers less than 2. Of the 454 immune children, 73 (16%) had measles HI titers between 2 and 8. These findings confirm durable immunity and a low rate of vaccine failure following live attenuated measles vaccination but demonstrate the importance of testing sera beginning at a dilution of 2 in order to detect children with low antibody levels. This survey also suggests that maternal antibody interferes with the active immune response in youngsters immunized when less than 1 year of age because this group of children had significantly lower geometric mean titers and significantly more susceptibles than the children immunized when greater than or minus 2 years.
1971年12月，对明尼阿波利斯郊区479名小学生的麻疹（风疹）免疫力进行了血清学调查。在这479名儿童中，25名（5.2%）血凝抑制（HI）滴度低于2。这些儿童被认为对麻疹易感。在233名无麻疹病史的免疫儿童中，13名（5.6%）风疹HI滴度低于2，而在98名有临床麻疹病史的儿童中，5名（5.1%）风疹HI滴度低于2。在454名免疫儿童中，73名（16%）麻疹HI滴度在2至8之间。这些发现证实了减毒活麻疹疫苗接种后持久的免疫力和较低的疫苗失败率，但表明从2倍稀释开始检测血清对于检测抗体水平较低的儿童很重要。这项调查还表明，母体抗体干扰了1岁以下免疫儿童的主动免疫反应，因为这组儿童的几何平均滴度明显较低，易感儿童明显多于2岁及以上免疫的儿童。
