Plowright W
J Hyg (Lond). 1984 Jun;92(3):285-96. doi: 10.1017/s0022172400064524.
The duration of immunity following a single administration of rinderpest cell culture vaccine, of 90 or more monolayer passages, was studied in E. African zebu (Boran) and grade (cross-bred European) cattle. All animals were kept for periods of 6-11 years in rinderpest-free environments; groups of them (in all 23 Borans and 10 grades) were then challenged by parenteral or intranasal inoculation of virulent virus or by contact exposure to reacting cattle. Nasal excretion of virus was studied daily over the 10-to 14-day period following challenge, and simultaneous attempts were made to detect viraemia. The neutralizing antibody response was followed at 6-month intervals over the whole post-vaccination period and then daily for 10 days and at longer intervals to 3 weeks after challenge. All 33 animals which were exposed by various routes failed to react clinically and a rinderpest viraemia was never detected. No transmission of virus from the vaccinates to susceptible in-contact controls occurred within 14 or more days, from the 20 animals which could be so tested. Clearcut serological responses to challenge were seen in six cattle (four Borans and two grades) which were challenged after 7 years or more; these reactions were all delayed to the 9th or 10th days, i.e. they were not typically 'anamnestic'. These results are discussed in relation to mass vaccination campaigns for the control of rinderpest and from the comparative viewpoint of measles vaccination in man.
在东非瘤牛（博拉牛）和杂交（欧洲杂交）牛中，研究了接种90代及以上单层传代的牛瘟细胞培养疫苗后免疫持续时间。所有动物在无牛瘟的环境中饲养6至11年；然后将它们分成几组（共23头博拉牛和10头杂交牛），通过肌肉注射或鼻内接种强毒病毒，或通过接触感染牛进行攻毒。在攻毒后的10至14天内，每天研究病毒的鼻腔排出情况，同时尝试检测病毒血症。在整个疫苗接种后的时期内，每隔6个月跟踪中和抗体反应，然后在攻毒后每天跟踪10天，并以更长的间隔跟踪至3周。通过各种途径攻毒的所有33只动物均未出现临床反应，也从未检测到牛瘟病毒血症。在14天或更长时间内，对20只可进行此项检测的接种动物，未发生病毒从接种动物传播至易感接触对照动物的情况。在7年或更长时间后接受攻毒的6头牛（4头博拉牛和2头杂交牛）中，观察到了明显的对攻毒的血清学反应；这些反应均延迟至第9天或第10天，即它们并非典型的“回忆反应”。结合控制牛瘟的大规模疫苗接种运动，并从人类麻疹疫苗接种的比较角度，对这些结果进行了讨论。
