乳铁蛋白和游离分泌成分与产肠毒素大肠杆菌的结合。
Binding of lactoferrin and free secretory component to enterotoxigenic Escherichia coli.
作者信息
de Oliveira I R, de Araújo A N, Bao S N, Giugliano L G
机构信息
Laboratório de Microbiologia, Departamento de Biologia Celular, Universidade de Brasilia, 70910-900 Brasilia DF, Brazil.
出版信息
FEMS Microbiol Lett. 2001 Sep 11;203(1):29-33. doi: 10.1111/j.1574-6968.2001.tb10816.x.
The ability of two glycoproteins of human milk, lactoferrin and free secretory component, to bind to Escherichia coli colonization factors (CFAs) was investigated using immunocytochemistry assays of enriched fimbrial extracts. The results revealed that lactoferrin binds to fimbrial CFA I adhesin but not to CFA II adhesin (CS1 and CS3), while free secretory component interacts with both CFA I and CFA II adhesins. Our data indicate that lactoferrin and free secretory component, which are very abundant proteins of human milk, could play an important role against infant enteric disease by blocking bacterial adhesion.
利用富集菌毛提取物的免疫细胞化学分析法，研究了人乳中的两种糖蛋白——乳铁蛋白和游离分泌成分——与大肠杆菌定植因子（CFAs）的结合能力。结果显示，乳铁蛋白可与菌毛CFA I黏附素结合，但不与CFA II黏附素（CS1和CS3）结合，而游离分泌成分则与CFA I和CFA II黏附素均有相互作用。我们的数据表明，乳铁蛋白和游离分泌成分是人乳中含量非常丰富的蛋白质，它们可能通过阻断细菌黏附，在预防婴幼儿肠道疾病方面发挥重要作用。
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