Bussolino F, Serini G, Mitola S, Bazzoni G, Dejana E
Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Italy.
EMBO Rep. 2001 Sep;2(9):763-7. doi: 10.1093/embo-reports/kve181.
An important unresolved issue related to tyrosine kinase receptor signaling pathways is the lack of specificity of the molecular effectors involved. The specificity of the biological responses that are nevertheless elicited may be explained by differences in activation thresholds, as well as by temporal (transient versus sustained) and topographical aspects of receptor activation. On the basis of recent lessons from endothelial cells, we argue that an additional strategy can be adopted to generate specificity, i.e. tyrosine kinase receptors may form distinct signaling modules with other transmembrane proteins, such as adhesive receptors, to elicit different biological programs in stimulated cells.
与酪氨酸激酶受体信号通路相关的一个重要未解决问题是所涉及的分子效应器缺乏特异性。然而，所引发的生物学反应的特异性可能由激活阈值的差异以及受体激活的时间（瞬时与持续）和拓扑学方面来解释。基于内皮细胞的最新研究经验，我们认为可以采用另一种策略来产生特异性，即酪氨酸激酶受体可能与其他跨膜蛋白（如黏附受体）形成不同的信号模块，以在受刺激细胞中引发不同的生物学程序。
