Glennon R A, Young R, Rosecrans J A, Kallman M J
Psychopharmacology (Berl). 1980;68(2):155-8. doi: 10.1007/BF00432133.
A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r = -0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).
在一个操作性条件反射箱中，通过两个杠杆的选择任务来训练24只大鼠，强化物为加糖牛奶，采用可变间隔15秒的强化程序，使其区分致幻剂（拟精神病药物）5-甲氧基-N,N-二甲基色胺（5-OMe DMT）和生理盐水给药。5-OMe DMT刺激以剂量相关的方式泛化到14种色胺相关类似物中的每一种。除一种化合物外，5-OMe DMT反应的有效剂量与5-羟色胺受体亲和力高度相关（r = -0.86）（使用离体大鼠胃底标本测定）。
