Fujie A, Muramatsu H, Yoshimura S, Hashimoto M, Shigematsu N, Takase S
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
J Antibiot (Tokyo). 2001 Jul;54(7):588-94. doi: 10.7164/antibiotics.54.588.
A novel antifungal antibiotic, FR901469, was isolated from an unidentified fungus No. 11243. It is a water-soluble 40-membered macrocyclic lipopeptidolactone, consisting of D-Ala, L-Tyr, L-Val, trans-4OH-L-Pro, trans-3OH-L-Pro, threo-3OH-L-Gln, Gly, L-Orn, L-Thr, three residues of D-alloThr and a (3R)-hydroxypalmitic acid. Its structure, including absolute configurations, was unequivocally determined as 1 based on chemical and spectroscopic evidence.
一种新型抗真菌抗生素FR901469，是从一株未鉴定的11243号真菌中分离得到的。它是一种水溶性的40元大环脂肽内酯，由D-丙氨酸、L-酪氨酸、L-缬氨酸、反式-4-羟基-L-脯氨酸、反式-3-羟基-L-脯氨酸、苏式-3-羟基-L-谷氨酰胺、甘氨酸、L-鸟氨酸、L-苏氨酸、三个D-别苏氨酸残基和一个(3R)-羟基棕榈酸组成。基于化学和光谱证据，其结构，包括绝对构型，被明确确定为1。
