Ishidoh Kei-Ichi, Kinoshita Hiroshi, Igarashi Yasuhiro, Ihara Fumio, Nihira Takuya
International Center for Biotechnology, Osaka University, Osaka, Japan.
Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
J Antibiot (Tokyo). 2014 Jun;67(6):459-63. doi: 10.1038/ja.2014.22. Epub 2014 Apr 2.
Verlamelin and its new derivative (verlamelin B) were isolated from fermentation broth of entomopathogenic fungus Lecanicillium sp. HF627. As the structural elucidation of verlamelin so far was only preliminary, we studied and determined the absolute structure of these two compounds to be cyclo(5S-hydroxytetradecanoic acid-D-alloThr/Ser-D-Ala-L-Pro-L-Gln-D-Tyr-L-Val). This is the first study that precisely analyzed the structure of verlamelin.
弗拉梅林及其新衍生物（弗拉梅林B）是从昆虫病原真菌蜡蚧轮枝菌HF627的发酵液中分离得到的。由于迄今为止对弗拉梅林的结构解析仅处于初步阶段，我们对这两种化合物进行了研究并确定其绝对结构为环（5S-羟基十四烷酸-D-阿洛苏氨酸/丝氨酸-D-丙氨酸-L-脯氨酸-L-谷氨酰胺-D-酪氨酸-L-缬氨酸）。这是首次对弗拉梅林结构进行精确分析的研究。
