A(1)、A(2A)和A(3)亚型腺苷受体调节小鼠眼压。
A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse.
作者信息
Avila M Y, Stone R A, Civan M M
机构信息
Department of Physiology, A303 Richards Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6085, USA.
出版信息
Br J Pharmacol. 2001 Sep;134(2):241-5. doi: 10.1038/sj.bjp.0704267.
Abstract
Despite the potential importance of the mouse in studying the pharmacology of aqueous dynamics, measurement of intraocular pressure (IOP) in its very small eye has been problematic. Utilizing a novel servo-null electrophysiologic approach recently applied to the mouse, we have identified a diversity of adenosine-receptor mechanisms in modulating IOP in this species. We report the first evidence that A(3) receptors increase IOP in any species, and verify in the mouse reports with larger mammals that A(1) receptors lower and A(2A) receptors increase IOP.
摘要
尽管小鼠在研究房水动力学药理学方面具有潜在重要性，但在其非常小的眼睛中测量眼压（IOP）一直存在问题。利用最近应用于小鼠的一种新型伺服零位电生理方法，我们在该物种中发现了多种调节眼压的腺苷受体机制。我们报告了首个证据，即A(3)受体在任何物种中都会升高眼压，并在小鼠中验证了与大型哺乳动物的报告一致，即A(1)受体降低眼压，A(2A)受体升高眼压。
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