Pryme I F, Bardocz S
Department of Biochemistry and Molecular Biology, University of Bergen, Arstadveien 19, NO-50009 Bergen, Norway.
Eur J Gastroenterol Hepatol. 2001 Sep;13(9):1041-6. doi: 10.1097/00042737-200109000-00007.
The growth of a murine non-Hodgkin lymphoma (NHL) tumour, either as an intraperitoneal ascites tumour or as a solid subcutaneous tumour, has been shown to be greatly reduced by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. The reduced rate of growth occurred in a dose-dependent manner. Based on the experimental observations it has been suggested that a competition occurs between the gut tissue undergoing hyperplasia and the developing tumour for nutrients (including polyamines) from a common body pool. This may be an important factor with regard to the observed initial low level of tumour growth following the feeding of a PHA-containing diet. Results showing that the level of hyperplasia of the small intestine in response to feeding the PHA diets was higher in non-injected mice compared to those which had been injected with tumour cells substantiated the concept of competition between gut and tumour for nutrients etc. required for growth. The observations suggest that lectins, which exhibit growth-promoting effects on the gut, may have interesting applications in the formulation of new approaches with respect to cancer treatment.
已表明，在饮食中加入植物血凝素（PHA），一种存在于生芸豆（菜豆）中的凝集素，可大大降低小鼠非霍奇金淋巴瘤（NHL）肿瘤的生长，该肿瘤既可作为腹腔腹水肿瘤，也可作为实体皮下肿瘤。生长速率的降低呈剂量依赖性。基于实验观察结果，有人提出，正在经历增生的肠道组织与正在发展的肿瘤之间会为来自共同身体储备的营养物质（包括多胺）展开竞争。这可能是喂食含PHA饮食后观察到肿瘤生长初期水平较低的一个重要因素。结果表明，与注射了肿瘤细胞的小鼠相比，未注射肿瘤细胞的小鼠在喂食PHA饮食后小肠的增生水平更高，这证实了肠道与肿瘤之间对生长所需营养物质等存在竞争的概念。这些观察结果表明，对肠道具有促生长作用的凝集素可能在制定新的癌症治疗方法方面具有有趣的应用。
