Pryme I F, Pusztai A, Bardocz S, Ewen S W
Department of Biochemistry and Molecular Biology, University of Bergen, Norway.
Histol Histopathol. 1998 Apr;13(2):575-83. doi: 10.14670/HH-13.575.
The growth of a transplantable murine non-Hodgkin lymphoma tumour, developing either intraperitoneally as an ascites tumour or subcutaneously as a solid tumour, has been shown to be markedly diminished by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. In NMRI mice fed PHA within the range 0.45-7.0 mg/g diet, tumours which developed during a 10 day period after subcutaneous injection of cells were about 35% of the dry weight of those in lactalbumin-fed (control) animals. The reduced rate of growth occurred in a dose-dependent manner within the range 0.45-3.5 mg/g diet. Based on these observations it has been suggested that a competition between the gut epithelium undergoing hyperplasia and the developing tumour may occur for nutrients from a common body pool, and this may be an important factor with regard to the observed initial low level of tumour growth following the feeding of a PHA-containing diet. Observations which showed that the level of hyperplasia of the small bowel in response to feeding the PHA diets was higher in non-injected mice compared to those which had been injected with tumour cells substantiated the concept of competition between gut and tumour for nutrients etc. required for growth. Experiments with a second murine tumour cell line (a plasmacytoma) in Balb/c mice gave similar results indicating that the effect of PHA was not restricted to a single tumour system.
可移植性小鼠非霍奇金淋巴瘤肿瘤，无论是作为腹水瘤在腹腔内生长，还是作为实体瘤在皮下生长，已表明在饮食中加入植物血凝素（PHA）（一种存在于生芸豆（菜豆属）中的凝集素）后，其生长会显著减缓。在饮食中PHA含量为0.45 - 7.0毫克/克的NMRI小鼠中，皮下注射细胞后10天内形成的肿瘤，其干重约为喂食乳白蛋白（对照）动物肿瘤干重的35%。在0.45 - 3.5毫克/克饮食范围内，生长速率降低呈剂量依赖性。基于这些观察结果，有人提出，正在经历增生的肠道上皮与正在生长的肿瘤之间可能会对来自共同体内库的营养物质展开竞争，这可能是喂食含PHA饮食后观察到肿瘤生长初始水平较低的一个重要因素。观察结果显示，与注射了肿瘤细胞的小鼠相比，未注射的小鼠在喂食PHA饮食后小肠增生水平更高，这证实了肠道与肿瘤之间对生长所需营养物质等存在竞争的概念。在Balb/c小鼠中对第二种小鼠肿瘤细胞系（浆细胞瘤）进行的实验也得到了类似结果，表明PHA的作用并不局限于单一肿瘤系统。
