Pryme I F, Pusztai A J, Grant G, Bardocz S
Department of Biochemistry and Molecular Biology, University of Bergen, Norway.
Cancer Lett. 1996 Jun 5;103(2):151-5. doi: 10.1016/0304-3835(96)04206-1.
Ten days after subcutaneous injection of MPC-11 cells, plasmacytoma tumours which developed in female Balb/c mice fed on a diet containing the kidney bean lectin phytohaemagglutinin (PHA) at a concentration of 7.0 mg g-1 diet, weighed only about 38% of those fed a lactalbumin (La) control diet. The reduction in growth caused by the lectin appeared to occur in a dose-dependent manner but the values did not reach significance before PHA was at a concentration of 7.0 mg g-1 diet. Pre-feeding with the lectin caused a further 50% reduction in tumour weight. In contrast to the reduction in tumour size the inclusion of PHA in the diet elevated the mean dry weight of the small intestine in a dose-dependent manner, values reaching significance at 3.5 mg g-1 diet. The results showed that gut hyperplasia was able to occur even in the presence of the developing tumour. A lypolytic effect of PHA occurred at high concentration. The observations suggest that PHA itself does not have a direct effect on the tumour cells, but an inter-relationship between gut hyperplasia and decreased tumour growth is indicated.
在皮下注射MPC - 11细胞10天后，以含浓度为7.0毫克/克饮食的菜豆凝集素植物血凝素（PHA）的饮食喂养的雌性Balb/c小鼠体内形成的浆细胞瘤肿瘤，其重量仅约为以乳白蛋白（La）对照饮食喂养的小鼠体内肿瘤重量的38%。凝集素引起的生长抑制似乎呈剂量依赖性，但在PHA浓度达到7.0毫克/克饮食之前，这些数值未达到显著水平。预先用凝集素喂养导致肿瘤重量进一步减少50%。与肿瘤大小的减小相反，饮食中添加PHA以剂量依赖性方式提高了小肠的平均干重，在3.5毫克/克饮食时数值达到显著水平。结果表明，即使在肿瘤生长的情况下，肠道增生也能够发生。高浓度时PHA产生脂解作用。这些观察结果表明，PHA本身对肿瘤细胞没有直接作用，但表明肠道增生与肿瘤生长减少之间存在相互关系。
