Leckie B J
Department of Medicine and Therapeutics, Leicester Royal Infirmary, Leicester, UK.
J Hypertens. 2001 Sep;19(9):1607-13. doi: 10.1097/00004872-200109000-00013.
Does captopril lower blood pressure in genetically hypertensive, normotensive and hypotensive mice under normal and salt-loaded conditions?
Groups of inbred mice that were genetically hypertensive, normotensive or hypotensive were given one of the following treatments: (a) captopril in drinking water for 7 days; controls were given water. (b) 0.85% saline to drink for up to 14 days; controls were given water. (c) Water or saline followed by captopril/water or captopril/saline for 7 days. (d) In hypotensive mice only, 0.85% saline, 0.85% saline plus captopril, water or captopril in water. Systolic blood pressures (SBP) were measured by a computerized tail-cuff sphygmomanometer. Results were compared by analysis of variance (ANOVA).
Captopril lowered SBP in all strains of mice. When saline was given with captopril, the fall in SBP was slower but the final SBP level was similar to that of mice given captopril in water. Hypotensive mice showed a transient rise in SBP on saline, which was abolished by concurrent treatment with captopril.
Captopril lowers blood pressure in hypertensive, normotensive and hypotensive mice. Salt-loading retards the captopril-induced fall in SBP, but the final level of SBP achieved is similar to that in mice given captopril with water. The BPL1 strain of mouse was slightly salt-sensitive, and this was abolished by captopril.
在正常和高盐条件下，卡托普利能否降低遗传性高血压、正常血压和低血压小鼠的血压？
将遗传性高血压、正常血压或低血压的近交系小鼠分组，给予以下处理之一：(a) 饮用水中添加卡托普利，持续7天；对照组给予水。(b) 饮用0.85%盐水，持续14天；对照组给予水。(c) 先给予水或盐水，随后给予卡托普利/水或卡托普利/盐水，持续7天。(d) 仅对低血压小鼠，给予0.85%盐水、0.85%盐水加卡托普利、水或水中加卡托普利。通过计算机化尾套血压计测量收缩压(SBP)。结果采用方差分析(ANOVA)进行比较。
卡托普利可降低所有品系小鼠的SBP。当卡托普利与盐水同时给予时，SBP下降较慢，但最终SBP水平与饮用卡托普利水溶液的小鼠相似。低血压小鼠在饮用盐水后SBP出现短暂升高，同时给予卡托普利可消除此现象。
卡托普利可降低高血压、正常血压和低血压小鼠的血压。高盐摄入会延缓卡托普利引起的SBP下降，但最终达到的SBP水平与饮用卡托普利水溶液的小鼠相似。BPL1品系小鼠对盐轻度敏感，卡托普利可消除此现象。
