缺氧细胞放射增敏剂NDPP对C3H小鼠实体瘤的适度放射增敏作用。
Modest radiosensitization of solid tumours in C3H mice by the hypoxic cell radiosensitizer NDPP.
作者信息
Sheldon P W, Smith A M
出版信息
Br J Cancer. 1975 Jan;31(1):81-8. doi: 10.1038/bjc.1975.10.
Abstract
The x-ray dose required to cure half the mice bearing first generation transplanted mammary carcinomata 150 days after irradiation was determined. NDPP proved to be a relatively poor radiosensitizer in mice, for although a maximum enhancement ratio of 1-3 was obtained when x-rays produced from a 1-4 MeVp electron accelerator were given between 10 and 17 min after the administration of NDPP, this was at a drug concentration sufficient to cause marked kidney abnormalities in 5-10% of the mice.
摘要
测定了在照射后150天治愈半数第一代移植性乳腺癌小鼠所需的X射线剂量。NDPP在小鼠中被证明是一种相对较差的放射增敏剂，因为尽管在给予NDPP后10至17分钟之间使用1 - 4MeVp电子加速器产生的X射线时，获得了最大增强比1 - 3，但此时药物浓度足以使5 - 10%的小鼠出现明显的肾脏异常。
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