Sheldon P W, Hill S A, Foster J L, Fowler J F
Br J Radiol. 1976 Jan;49(577):76-80. doi: 10.1259/0007-1285-49-577-76.
Three fractionated X-ray schedules were used, with and without the electron-affinic radiosensitizer of hypoxic cells, Ro-07-0582, to determine the local control of first-generation transplants of spontaneous mammary tumours in C3H mice. Three or five fractions were given in either four or nine days overall time. The results were compared with acute skin reactions in other mice caused by the same treatment schedules. For a given skin reaction, the local control of tumours varied widely, from good to bad, when different X-ray only schedules were used. All three schedules using Ro-07-0582 however yielded good results. It appears that the use of the hypoxic-cell radiosensitizer took the unreliability out of these short fractionated treatments.
采用了三种分次X射线照射方案，分别使用和不使用低氧细胞亲电子放射增敏剂Ro-07-0582，以确定C3H小鼠自发性乳腺肿瘤第一代移植瘤的局部控制情况。在总共4天或9天的时间内给予3次或5次照射。将结果与相同照射方案在其他小鼠中引起的急性皮肤反应进行比较。对于给定的皮肤反应，当使用不同的仅X射线照射方案时，肿瘤的局部控制差异很大，从好到差。然而，所有使用Ro-07-0582的三种方案都产生了良好的结果。看来使用低氧细胞放射增敏剂消除了这些短程分次治疗的不可靠性。
