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1
Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug.一种2-硝基咪唑类药物对C3H小鼠乳腺肿瘤的放射增敏作用。
Br J Cancer. 1974 Dec;30(6):560-5. doi: 10.1038/bjc.1974.235.
2
Optimum fractionation of the C3H mouse mammary carcinoma using x-rays, the hypoxic-cell radiosensitizer Ro-07-0582, or fast neutrons.使用X射线、乏氧细胞放射增敏剂Ro-07-0582或快中子对C3H小鼠乳腺癌进行最佳分割放疗。
Int J Radiat Oncol Biol Phys. 1976 Jul-Aug;1(7-8):579-92. doi: 10.1016/0360-3016(76)90139-5.
3
Radiosensitization of C3H mouse mammary tumours using fractionated doses of x rays with the drug Ro-07-0582.使用药物Ro-07-0582和分次剂量X射线对C3H小鼠乳腺肿瘤进行放射增敏
Br J Radiol. 1976 Jan;49(577):76-80. doi: 10.1259/0007-1285-49-577-76.
4
Enhanced local tumour control after single or fractionated radiation treatment using the hypoxic cell radiosensitizer doranidazole.使用缺氧细胞放射增敏剂多柔比星唑进行单次或分次放射治疗后增强局部肿瘤控制。
Radiother Oncol. 2008 Jun;87(3):331-8. doi: 10.1016/j.radonc.2008.03.002. Epub 2008 Mar 28.
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Studies in radiosensitizing effects of misonidazole and SR-2508 on C3H/He mouse mammary tumors.米索硝唑和SR-2508对C3H/He小鼠乳腺肿瘤的放射增敏作用研究。
Radiat Med. 1984 Jan-Mar;2(1):71-5.
6
[Effect of the hypoxic cell radiosensitizer,a dinitroimidazole derivative, on murine tumors].[缺氧细胞放射增敏剂（一种二硝基咪唑衍生物）对小鼠肿瘤的影响]
Nihon Igaku Hoshasen Gakkai Zasshi. 1986 Dec 25;46(12):1442-3.
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Modest radiosensitization of solid tumours in C3H mice by the hypoxic cell radiosensitizer NDPP.缺氧细胞放射增敏剂NDPP对C3H小鼠实体瘤的适度放射增敏作用。
Br J Cancer. 1975 Jan;31(1):81-8. doi: 10.1038/bjc.1975.10.
8
The response of a transplantable tumor to fractionated irradiation. 1. X rays and the hypoxic cell radiosensitizer Ro-07-0582.可移植肿瘤对分次照射的反应。1. X射线与乏氧细胞放射增敏剂Ro-07-0582
Radiat Res. 1976 Apr;66(1):66-75.
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In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation.新型氟化低氧细胞放射增敏剂KU-2285联合放射剂量分割的体内放射增敏活性
Int J Radiat Oncol Biol Phys. 1991 Oct;21(5):1231-4. doi: 10.1016/0360-3016(91)90280-h.
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Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.RO-07-0582对实验小鼠肿瘤中缺氧细胞的放射增敏和杀细胞作用以及X线损伤的修复
Br J Cancer. 1977 Apr;35(4):461-9. doi: 10.1038/bjc.1977.69.

引用本文的文献

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Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers.设计、合成及硝基咪唑类放射增敏剂的抗癌评估。
Molecules. 2023 May 31;28(11):4457. doi: 10.3390/molecules28114457.
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Synthesis and characterization of a hypoxia-sensitive MRI probe.缺氧敏感性 MRI 探针的合成与表征。
Chemistry. 2012 Jul 27;18(31):9669-76. doi: 10.1002/chem.201200266. Epub 2012 Jun 27.
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New developments in radiation therapy for head and neck cancer: intensity-modulated radiation therapy and hypoxia targeting.头颈部癌放射治疗的新进展：调强放射治疗与缺氧靶向治疗
Semin Oncol. 2008 Jun;35(3):236-50. doi: 10.1053/j.seminoncol.2008.03.003.
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A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors.一种新型的缺氧依赖性2-硝基咪唑KIN-841通过阻断血管生成因子的产生来抑制肿瘤特异性血管生成。
Br J Cancer. 2003 Jan 27;88(2):307-13. doi: 10.1038/sj.bjc.6600667.
5
Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer.以米索硝唑作为乏氧细胞增敏剂对大鼠脑肿瘤进行放射治疗。
J Cancer Res Clin Oncol. 1985;109(3):188-92. doi: 10.1007/BF00390355.
6
Modest radiosensitization of solid tumours in C3H mice by the hypoxic cell radiosensitizer NDPP.缺氧细胞放射增敏剂NDPP对C3H小鼠实体瘤的适度放射增敏作用。
Br J Cancer. 1975 Jan;31(1):81-8. doi: 10.1038/bjc.1975.10.
7
Further investigations of the effects of the hypoxic-cell radiosensitizer, Ro-07-0582, on local control of a mouse tumour.对缺氧细胞放射增敏剂Ro-07-0582对小鼠肿瘤局部控制效果的进一步研究。
Br J Cancer. 1977 Aug;36(2):198-205. doi: 10.1038/bjc.1977.178.
8
Cytotoxicity of Ro-07-0582; enhancement by hyperthermia and protection by cysteamine.Ro-07-0582的细胞毒性；热疗增强作用及半胱胺的保护作用
Br J Cancer. 1977 Jun;35(6):809-15. doi: 10.1038/bjc.1977.122.
9
Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice.缺氧细胞放射增敏剂与小鼠移植瘤的X射线局部控制
Br J Cancer. 1977 Jun;35(6):795-808. doi: 10.1038/bjc.1977.121.
10
Radiosensitizing and cytocidal effects on hypoxic cells of RO-07-0582, and repair of x-ray injury, in an experimental mouse tumour.RO-07-0582对实验小鼠肿瘤中缺氧细胞的放射增敏和杀细胞作用以及X线损伤的修复
Br J Cancer. 1977 Apr;35(4):461-9. doi: 10.1038/bjc.1977.69.

本文引用的文献

1
The histological structure of some human lung cancers and the possible implications for radiotherapy.一些人类肺癌的组织学结构及其对放射治疗的可能影响。
Br J Cancer. 1955 Dec;9(4):539-49. doi: 10.1038/bjc.1955.55.
2
Studies of the toxicity and radiosensitising activity of triacetoneamine-N-oxyl in mice.三丙酮胺 -N- 氧基在小鼠体内的毒性和放射增敏活性研究。
Br J Radiol. 1970 Feb;43(506):91-6. doi: 10.1259/0007-1285-43-506-91.
3
Induction of lung tumors and malignant lymphomas in mice by metronidazole.甲硝唑诱导小鼠肺部肿瘤和恶性淋巴瘤
J Natl Cancer Inst. 1972 Mar;48(3):721-9.
4
Current aspects of radiobiology as applied to radiotherapy.放射生物学应用于放射治疗的当前进展。
Clin Radiol. 1972 Jul;23(3):257-62. doi: 10.1016/s0009-9260(72)80042-4.
5
A comparison of the response of tumour and normal tissue in the mouse exposed to single doses of fast neutrons or electrons.对暴露于单剂量快中子或电子的小鼠体内肿瘤组织和正常组织反应的比较。
Br J Radiol. 1970 Dec;43(516):894-7. doi: 10.1259/0007-1285-43-516-894.
6
Letter: "High-dose" metronidazole: a preliminary pharmacological study prior to its investigational use in clinical radiotherapy trials.信函：“高剂量”甲硝唑：在临床放射治疗试验中进行研究性使用之前的初步药理学研究。
Br J Radiol. 1974 May;47(557):297-9. doi: 10.1259/0007-1285-47-557-297-c.
7
Effectiveness of nitrofuran derivatives in sensitizing hypoxic mammalian cells to x rays.硝基呋喃衍生物使缺氧哺乳动物细胞对X射线敏感的有效性。
Br J Radiol. 1973 Aug;46(548):623-30. doi: 10.1259/0007-1285-46-548-623.
8
Metronidazole ("Flagyl"). A radiosensitizer of hypoxic cells.甲硝唑（“灭滴灵”）。一种缺氧细胞的放射增敏剂。
Br J Radiol. 1974 Aug;47(560):474-81. doi: 10.1259/0007-1285-47-560-474.
9
Chemical radiosensitization of hypoxic cells.缺氧细胞的化学放射增敏作用。
Br Med Bull. 1973 Jan;29(1):48-53. doi: 10.1093/oxfordjournals.bmb.a070956.
10
Carcinogenicity of 5-nitrofurans, 5-nitroimidazoles, 4-nitrobenzenes, and related compounds.5-硝基呋喃、5-硝基咪唑、4-硝基苯及相关化合物的致癌性。
J Natl Cancer Inst. 1973 Aug;51(2):403-17.

一种2-硝基咪唑类药物对C3H小鼠乳腺肿瘤的放射增敏作用。

Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug.

作者信息

Sheldon P W, Foster J L, Fowler J F

出版信息

Br J Cancer. 1974 Dec;30(6):560-5. doi: 10.1038/bjc.1974.235.

DOI:10.1038/bjc.1974.235
PMID:4451633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009326/
Abstract

Local tumour control has been determined at 150 days after single doses of 240 kV x-rays given with or without 1 mg/g body weight of the hypoxic cell radiosensitizer Ro-07-0582. The dose required to control 50% of the tumours (TCD50) was reduced from 4380 to 2410 rad, yielding an enhancement ratio of 1·82 ± 0·07 s.e.mean. This compares favourably with the corresponding single dose gain factor for fast neutrons, which was about 1·7.

摘要

在给予单剂量240 kV X射线（无论有无1 mg/g体重的乏氧细胞放射增敏剂Ro-07-0582）后150天测定局部肿瘤控制情况。控制50%肿瘤所需的剂量（TCD50）从4380拉德降至2410拉德，增强比为1.82±0.07（标准误均值）。这与快中子相应的单剂量增益因子相比很有利，后者约为1.7。