一种2-硝基咪唑类药物对C3H小鼠乳腺肿瘤的放射增敏作用。
Radiosensitization of C3H mouse mammary tumours by a 2-nitroimidazole drug.
作者信息
Sheldon P W, Foster J L, Fowler J F
出版信息
Br J Cancer. 1974 Dec;30(6):560-5. doi: 10.1038/bjc.1974.235.
Abstract
Local tumour control has been determined at 150 days after single doses of 240 kV x-rays given with or without 1 mg/g body weight of the hypoxic cell radiosensitizer Ro-07-0582. The dose required to control 50% of the tumours (TCD50) was reduced from 4380 to 2410 rad, yielding an enhancement ratio of 1·82 ± 0·07 s.e.mean. This compares favourably with the corresponding single dose gain factor for fast neutrons, which was about 1·7.
摘要
在给予单剂量240 kV X射线（无论有无1 mg/g体重的乏氧细胞放射增敏剂Ro-07-0582）后150天测定局部肿瘤控制情况。控制50%肿瘤所需的剂量（TCD50）从4380拉德降至2410拉德，增强比为1.82±0.07（标准误均值）。这与快中子相应的单剂量增益因子相比很有利，后者约为1.7。
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