人乳腺癌组织中17β-雌二醇的生物合成及其表征的新方法。
Biosynthesis of 17beta-oestradiol in human breast carcinoma tissue and a novel method for its characterization.
作者信息
Adams J B, Li K
出版信息
Br J Cancer. 1975 Apr;31(4):429-33. doi: 10.1038/bjc.1975.82.
Abstract
Conversion of 7alpha3H-testosterone to 17beta-oestradiol by human mammary carcinoma tissue in vitro has been demonstrated. It was characterized unequivocally by conversion to 17beta-oestradiol-3-sulphate upon incubation with adenosine-3'-phosphate-5'-phosphosulphate and the highly specific enzyme oestrogen sulphotransferase.
摘要
已证实在体外人乳腺癌组织可将7α³H-睾酮转化为17β-雌二醇。通过与腺苷-3'-磷酸-5'-磷酸硫酸酯及高特异性酶雌激素硫酸转移酶一起孵育转化为17β-雌二醇-3-硫酸盐，从而明确了其特征。
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本文引用的文献
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The enzymic synthesis of the sulfate esters of estradiol-17beta and diethylstilbesterol.雌二醇 - 17β和己烯雌酚硫酸酯的酶促合成。
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