Li K, Chandra D P, Foo T, Adams J B, McDonald D
Steroids. 1976 Oct;28(4):561-74. doi: 10.1016/0039-128x(76)90024-6.
The ability of human mammary tumors to convert 7alpha 3H-testerone to estrogens was examined in order to determine whether this bore any relationship to estrogen receptor and steroid sulfurylation levels; such levels being indicative of hormone dependency. In 8 out of 9 tumors, formation of estradiol-17beta from testosterone was demonstrated. Those tumors showing the lowest conversion of testosterone to estradiol-17beta possessed the highest levels of dehydroepiandrosterone sulfotransferase which lends support to data implicating sulfurylation in the regulation of steroid metabolism in human tumors. All tumors activated sulfate to adenosine-3'-phospho-5'-phosphosulfate and the concentrations were significantly correlated withe the recorded levels of dehydroepiandrosterone sulfate. Estrogen receptor levels did not show any obvious relationship to the other parameters.
为了确定人类乳腺肿瘤将7α 3H-睾酮转化为雌激素的能力是否与雌激素受体及类固醇硫酸化水平存在任何关联（这些水平表明激素依赖性），对其进行了检测。在9个肿瘤中有8个显示出能从睾酮形成雌二醇-17β。那些将睾酮转化为雌二醇-17β最少的肿瘤，其脱氢表雄酮硫酸转移酶水平最高，这支持了有关硫酸化参与人类肿瘤类固醇代谢调节的数据。所有肿瘤都将硫酸盐激活为3'-磷酸-5'-磷酸腺苷硫酸，其浓度与记录的硫酸脱氢表雄酮水平显著相关。雌激素受体水平与其他参数未显示出任何明显关联。
