Kevorkian G A, Marukhyan G L, Arakelyan L N, Guevorkian A G, Galoyan A A
H. Buniatian Institute of Biochemistry of NAS, Yerevan, Republic of Armenia.
Neurochem Res. 2001 Jul;26(7):829-32. doi: 10.1023/a:1011668203758.
The number of publications on the investigation of crush syndrome (CS) pathogenesis at traumatic toxicosis is rather limited. The influence of some pharmacological preparations on the development of CS pathogenesis is not very well clarified. Proline-rich peptide (PRP) is a fragment of a glycopeptide comprising the carboxyterminus of the neurohypophyseal vasopressin-neurophysin precursor isolated from the bovine neurohypophysis neurosecretory granules. The polypeptide possesses stimulating activity on differentiation and proliferation of T-lymphocytes and Interleukin-2 (Il-2) biosynthesis. The experimental model of CS of white rats was induced by 2-h of compression followed by 2, 24, and 48-h of decompression of femoral muscle tissue. The influence of PRP on [14C]glucose utilization was investigated in brain, heart, and kidney tissues. The level of [14C]glucose utilization decreased in brain during compression followed by 2-h and 24-h of decompression, while it increased under the influence of PRP at all decompression periods. The influence of PRP on the myocardium and kidneys differs, depending on its nature and on the periods of decompression.
关于创伤中毒时挤压综合征（CS）发病机制研究的出版物数量相当有限。一些药物制剂对CS发病机制发展的影响尚未完全阐明。富含脯氨酸的肽（PRP）是一种糖肽片段，由从牛神经垂体神经分泌颗粒中分离出的神经垂体加压素-神经垂体素前体的羧基末端组成。该多肽对T淋巴细胞的分化和增殖以及白细胞介素-2（Il-2）的生物合成具有刺激活性。通过对大鼠股部肌肉组织进行2小时压迫，随后分别在2小时、24小时和48小时进行减压，建立了CS实验模型。研究了PRP对脑、心脏和肾脏组织中[14C]葡萄糖利用的影响。在压迫期间以及随后2小时和24小时减压过程中，脑内[14C]葡萄糖利用水平下降，而在所有减压阶段，PRP作用下该水平升高。PRP对心肌和肾脏的影响因PRP的性质和减压时期而异。
