Gentry W C, Reed W B, Siegel J M
Birth Defects Orig Artic Ser. 1975;11(4):137-41.
Cowden disease represents an unusual, but unique syndrome which can be recognized most consistently by the development of characteristic verrucous, keratotic, papular, and nodular lesions about facial orifices, on the oral mucosa, and over the dorsal surfaces of the forearms and hands. The cause of these diverse hyperplastic changes is not known. Recognition of these lesions as signs of more extensive disease should alert the physician to examine the thyroid gland, breasts, female reproductive tract, GI tract, and skeleton for evidence of the associated changes we have enumerated. Because of the tendency for lesions of the thyroid, breast, and intestines to undergo malignant change, these patients require close observation and evaluation.
考登病是一种不常见但独特的综合征，其最具特征性的表现是在面部孔窍周围、口腔黏膜以及前臂和手部背侧出现特征性的疣状、角化性、丘疹性和结节性损害。这些多样的增生性改变的病因尚不清楚。认识到这些损害是更广泛疾病的体征，应提醒医生检查甲状腺、乳房、女性生殖道、胃肠道和骨骼，以寻找我们所列举的相关改变的证据。由于甲状腺、乳房和肠道的损害有恶变倾向，这些患者需要密切观察和评估。
