Starink T M
J Am Acad Dermatol. 1984 Dec;11(6):1127-41. doi: 10.1016/s0190-9622(84)70270-2.
Fourteen new patients with Cowden's disease from the Netherlands were analyzed and compared with the sixty-nine previously reported patients. The full clinical spectrum of the disease can now be fairly well delineated. Mucocutaneous lesions, especially facial trichilemmomas and other follicular malformations, acral keratoses, and oral papillomas, remain the most constant findings. The incidence of each of these mucocutaneous findings was slightly higher than reported previously, probably reflecting increasing experience with this condition. Also our patients tended to have more extensive acral keratoses and perhaps less extensive facial lesions. In one family there was an extremely high incidence of lipomas. Breast cancer was seen in three of our twelve female patients, reflecting the trend toward a lower incidence of breast cancer in the recent literature. Gastrointestinal polyps in one family were much more common than previously reported, occurring in five of seven patients. Thyroid disease was found in about two thirds of the patients and abnormalities of the female reproductive system in slightly more than half of the patients, both incidences being approximately the same as in the literature. With increased awareness of the condition it is likely that many more cases will be recognized in the future.
对来自荷兰的14例新的考登病患者进行了分析，并与之前报告的69例患者进行了比较。现在可以相当清晰地勾勒出该疾病的完整临床谱系。皮肤黏膜病变，尤其是面部毛发上皮瘤和其他毛囊畸形、肢端角化病和口腔乳头状瘤，仍然是最常见的表现。这些皮肤黏膜表现的发生率均略高于之前的报告，这可能反映了对该疾病的认识不断增加。此外，我们的患者往往有更广泛的肢端角化病，面部病变可能较少。在一个家族中，脂肪瘤的发病率极高。我们的12名女性患者中有3例患有乳腺癌，这反映了近期文献中乳腺癌发病率较低的趋势。一个家族中的胃肠道息肉比之前报告的更为常见，7名患者中有5例出现。约三分之二的患者发现患有甲状腺疾病，略多于一半的患者存在女性生殖系统异常，这两种疾病的发病率与文献报道大致相同。随着对该疾病认识的提高，未来可能会发现更多病例。
