Brück A, Portin R, Lindell A, Laihinen A, Bergman J, Haaparanta M, Solin O, Rinne J O
Turku PET Centre, University of Turku, FIN-20520, Turku, Finland.
Neurosci Lett. 2001 Sep 28;311(2):81-4. doi: 10.1016/s0304-3940(01)02124-3.
We examined the relation between the dopaminergic function and the cognitive performance of patients with Parkinson's disease (PD). The subject sample consisted of ten patients in the early course of PD and with no previous antiparkinsonian medication. The dopaminergic function of the caudate nucleus and the putamen was studied with [(18)F]fluorodopa positron emission tomography, and the cognitive performance with a comprehensive battery of neuropsychological tests including tests sensitive to frontal lobe function. The decreased [(18)F]fluorodopa uptake in the right caudate nucleus was found to be related to slow processing time, measured as the difference between the incongruent and the congruent subtests of the Stroop Test (r=-0.85, P=0.002), a similar trend was seen in the left caudate (r=-0.60, P=0.07). Similar correlation was not detected in the putamen. The present findings provide evidence that the decreased dopaminergic function in the right caudate nucleus is related to the impaired performance in tests sensitive to frontal lobe function in patients at an early stage of PD and with no antiparkinsonian medication.
我们研究了帕金森病（PD）患者的多巴胺能功能与认知表现之间的关系。受试者样本包括10名处于PD病程早期且未曾服用过抗帕金森药物的患者。采用[（18）F]氟多巴正电子发射断层扫描研究尾状核和壳核的多巴胺能功能，并用包括对额叶功能敏感的测试在内的一系列全面的神经心理学测试评估认知表现。结果发现，右侧尾状核中[（18）F]氟多巴摄取减少与处理时间延长有关，处理时间通过斯特鲁普测验中不一致和一致子测验之间的差异来衡量（r = -0.85，P = 0.002），左侧尾状核也有类似趋势（r = -0.60，P = 0.07）。在壳核中未检测到类似的相关性。目前的研究结果表明，在未服用抗帕金森药物的PD早期患者中，右侧尾状核多巴胺能功能降低与对额叶功能敏感的测试中表现受损有关。
