Altman N R, Bernal B
Department of Radiology, Miami Children's Hospital, 3100 SW 62nd Ave, Miami, FL 33155, USA.
Radiology. 2001 Oct;221(1):56-63. doi: 10.1148/radiol.2211010074.
To map developing areas of activation with functional magnetic resonance (MR) imaging in sedated children by using passive auditory and visual tasks.
Forty children between 2 months and 9 years old were examined and grouped according to age. Children were selected from patients referred to undergo brain MR imaging. Patients received pentobarbital (3.0-7.0 mg per kilogram of body weight) or chloral hydrate (50-75 mg/kg). The functional MR imaging study was performed at the end of the examination. Paradigms consisted of flashing lights at 8 Hz displayed on special goggles and a prerecorded mother's voice presented through headphones. Activation maps were obtained from a paired t test with a P value of.0005 (uncorrected).
The visual stimulus produced statistically significant negative values in the rostral aspect of the primary visual area (28 [90%] of 31 patients). The auditory paradigm activated either temporal or frontal areas in 26 (68%) of 31 patients. There was more frontal activation in the older children.
Visual and auditory cortices can be activated in children who have been sedated. Visual responses show negative values in the rostral visual cortex, independent of age. Auditory activation is seen in temporal and frontal lobes.
通过使用被动听觉和视觉任务，利用功能磁共振成像（MRI）描绘镇静儿童激活的发育区域。
对40名年龄在2个月至9岁之间的儿童进行检查，并根据年龄分组。儿童选自转诊接受脑部MRI检查的患者。患者接受戊巴比妥（3.0 - 7.0毫克/千克体重）或水合氯醛（50 - 75毫克/千克）。功能MRI研究在检查结束时进行。范式包括通过特殊护目镜以8赫兹闪烁的灯光以及通过耳机播放的预先录制的母亲声音。通过配对t检验获得激活图，P值为0.0005（未校正）。
视觉刺激在31名患者中的28名（90%）初级视觉区域的喙侧产生了具有统计学意义的负值。听觉范式在31名患者中的26名（68%）激活了颞叶或额叶区域。年龄较大的儿童额叶激活更多。
镇静儿童的视觉和听觉皮层可以被激活。视觉反应在喙侧视觉皮层显示负值，与年龄无关。听觉激活见于颞叶和额叶。
