Manuskiatti W, Fitzpatrick R E, Goldman M P
Dermatology Associates and Cosmetic Laser Associates of San Diego County, Inc, La Jolla, CA 92037, USA.
J Am Acad Dermatol. 2001 Oct;45(4):557-65. doi: 10.1067/mjd.2001.116580.
The 585-nm flashlamp-pumped pulsed-dye laser (PDL) has proven to be the treatment of choice for certain keloids and hypertrophic scars, but the precise fluence, numbers of treatment, and treatment interval remain anecdotal.
This study was performed to determine whether the therapeutic outcome of the PDL varies with the energy density (fluence) of the laser pulses and numbers of treatment.
Ten previously untreated, erythematous, keloidal or hypertrophic median sternotomy scars of 10 patients were divided into 4 segments and were randomly treated with a 585-nm PDL at a fluence of 3, 5, and 7 J/cm(2) to 3 of 4 segments every 4 weeks for a total of 6 treatment sessions. One segment of each patient's scars was untreated and served as a control. Clinical improvement including scar height, erythema, and pliability was evaluated before treatment and every 8 weeks for a total period of 32 weeks. Self-assessment was also determined by patients on a 25% increment of improvement scale comparing week 0 and week 32.
A significant improvement in scar height, erythema, and pliability was noted in all laser-treated scar areas. There was no significant difference in treatment outcome versus the fluence of the laser (3, 5, and 7 J/cm(2)), although there was a trend for lower fluences to show more improvement. Objective clinical improvement was seen as early as week 16, after more than two treatments were given. Multiple treatments (>2) appeared to provide a greater percentage of scar resolution.
The clinical improvement of scars after PDL treatment demonstrates no statistically significant fluence dependence in this study, but a trend toward better response with lower fluences is seen. In addition, multiple treatment sessions are suggested for achieving greater response.
585纳米闪光灯泵浦脉冲染料激光(PDL)已被证明是某些瘢痕疙瘩和增生性瘢痕的首选治疗方法,但精确的能量密度、治疗次数和治疗间隔仍缺乏科学依据。
本研究旨在确定PDL的治疗效果是否随激光脉冲的能量密度(能量)和治疗次数而变化。
将10例患者先前未经治疗的、发红的胸骨正中切开术后瘢痕疙瘩或增生性瘢痕分为4段,每4周对4段中的3段分别用能量密度为3、5和7 J/cm²的585纳米PDL进行随机治疗,共治疗6次。每位患者瘢痕的1段不予治疗作为对照。在治疗前以及每8周进行一次评估,共评估32周,评估内容包括瘢痕高度、红斑和柔韧性等临床改善情况。还让患者进行自我评估,比较第0周和第32周,以25%的改善幅度递增。
所有激光治疗的瘢痕区域在瘢痕高度、红斑和柔韧性方面均有显著改善。治疗效果与激光能量密度(3、5和7 J/cm²)之间无显著差异,尽管能量密度较低时似乎有改善更明显的趋势。在进行了两次以上治疗后,早在第16周就观察到了客观的临床改善。多次治疗(>2次)似乎能使瘢痕消退的比例更高。
在本研究中,PDL治疗后瘢痕的临床改善在统计学上没有显示出对能量密度的显著依赖性,但能量密度较低时反应更好的趋势是可见的。此外,建议进行多次治疗以获得更好的反应。