Alster T S, Williams C M
Department of Medicine, Georgetown University Medical Center, Washington, DC, USA.
Lancet. 1995 May 13;345(8959):1198-200. doi: 10.1016/s0140-6736(95)91989-9.
Despite increasing knowledge of wound healing and collagen metabolism, hypertrophic scars and keloid scars are difficult to eradicate. Median sternotomy scars are often hypertrophic or keloidal. We treated them with a 585 nm flashlamp-pumped pulsed-dye laser, which selectively injures cutaneous microvessels without inducing scars. 16 adult patients with hypertrophic or keloidal median sternotomy scars after heart surgery received two treatments to one half of their previously untreated scars every 6-8 weeks and were reviewed at 6 months. Symptoms and clinical, histological, photographic, and surface texture assessments were obtained for treated and untreated areas of scar and evaluated independently by two observers blind to the treatment and by digital image analysis of skin surface casts. There was a significant improvement in erythema, scar height, skin surface texture, and pruritus in laser-treated scar areas; this improvement persisted for at least 6 months.
尽管对伤口愈合和胶原蛋白代谢的了解不断增加,但增生性瘢痕和瘢痕疙瘩仍难以根除。正中胸骨切开术瘢痕常常是增生性或瘢痕疙瘩性的。我们用585nm闪光灯泵浦脉冲染料激光治疗这些瘢痕,该激光可选择性地损伤皮肤微血管而不形成瘢痕。16例心脏手术后有增生性或瘢痕疙瘩性正中胸骨切开术瘢痕的成年患者,每6 - 8周对其之前未治疗瘢痕的一半进行两次治疗,并在6个月时进行复查。对瘢痕的治疗区和未治疗区进行症状、临床、组织学、照片及表面纹理评估,并由两名对治疗不知情的观察者独立评估,同时对皮肤表面铸型进行数字图像分析。激光治疗的瘢痕区域在红斑、瘢痕高度、皮肤表面纹理和瘙痒方面有显著改善;这种改善至少持续6个月。