Dubin J A, Müller H G, Wang J L
Department of Epidemiology and Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA.
Stat Med. 2001 Oct 15;20(19):2951-64. doi: 10.1002/sim.888.
A compact graphical device for combining survival and time-varying covariate information is proposed. The proposed graph contains the Kaplan-Meier estimator for right-censored data and a simultaneous display of the behaviour of time-dependent covariate(s) and the lifetime for each subject in the sample. The observed levels of time-dependent covariates are possibly subjected to an initial dimension reduction or smoothing step to produce a continuous covariate function. Values of this function are plotted on a horizontal bar for the length of the lifetime of the subject. Covariate information for censored data is also incorporated. The union of the horizontal bars forms the Kaplan-Meier estimator of the survival function. Our graphical method is implemented with a new S-plus function and demonstrated in several applications.
提出了一种用于合并生存信息和随时间变化的协变量信息的紧凑型图形设备。所提出的图形包含用于右删失数据的Kaplan-Meier估计器,并同时展示了随时间变化的协变量的行为以及样本中每个受试者的生存期。观察到的随时间变化的协变量水平可能会经过初始降维或平滑步骤,以生成一个连续的协变量函数。该函数的值针对受试者生存期的长度绘制在水平条上。删失数据的协变量信息也被纳入其中。水平条的并集形成了生存函数的Kaplan-Meier估计器。我们的图形方法通过一个新的S-plus函数实现,并在多个应用中得到了展示。