Lénárd Z, Studinger P, Kováts Z, Reneman R, Kollai M
Institute of Human Physiology and Clinical Experimental Research, Semmelweis University of Medicine, Budapest, Hungary.
Auton Neurosci. 2001 Sep 17;92(1-2):92-9. doi: 10.1016/S1566-0702(01)00309-5.
We compared aortic arch (AA) and carotid sinus (CS) distensibility, and determined the relationship between baroreflex sensitivity (BRS) and distensibility coefficients of AA and CS (DCAA and DCCS, respectively). In 47 healthy 19-71-year-old subjects, AA and CS end-diastolic diameter (D) and pulsatile distension (delta D) was measured with ultrasound and arterial pressure by sphygmomanometer and Finapres. DC was calculated as 2delta D/(D x delta P), where delta P is the pulse pressure. BRS was determined by the sequence method. Data are given as mean +/- S.D.; significance was set at p < 0.05. DCAA and DCCS were linearly related across subjects (r = 0.80, p < 0.001). No difference between DCAA and DCCS (3.8 +/- 1.4 x 10(-3) and 4.2 + 2.2 x 10(-3) mm Hg(-1), respectively) was found for all subjects (paired t-test). However, at ages < 35 years, DCCS exceeded DCAA, whereas this relation was reversed at ages > 35 years. Age accounted for 53% of variability in DCAA and 73% of variability in DCCS. BRS was related to DC (linear regression), with the BRS-DCAA relation being steeper and closer (r = 0.73, p < 0.001) than the BRS-DCCS relation (r = 0.54, p < 0.05). It is suggested that aortic baroreceptors may have a dominant role in heart rate control.
我们比较了主动脉弓（AA）和颈动脉窦（CS）的可扩张性，并确定了压力反射敏感性（BRS）与AA和CS的扩张系数（分别为DCAA和DCCS）之间的关系。在47名年龄在19至71岁的健康受试者中，使用超声测量AA和CS的舒张末期直径（D）和搏动性扩张（ΔD），并使用血压计和Finapres测量动脉压。DC计算为2ΔD/（D×ΔP），其中ΔP为脉压。通过序列法测定BRS。数据以平均值±标准差表示；显著性设定为p<0.05。跨受试者的DCAA和DCCS呈线性相关（r=0.80，p<0.001）。所有受试者的DCAA和DCCS之间无差异（分别为3.8±1.4×10⁻³和4.2+2.2×10⁻³mmHg⁻¹）（配对t检验）。然而，在年龄<35岁时，DCCS超过DCAA，而在年龄>35岁时，这种关系则相反。年龄占DCAA变异性的53%，占DCCS变异性的73%。BRS与DC相关（线性回归），BRS-DCAA关系比BRS-DCCS关系更陡峭、更紧密（r=0.73，p<0.001）（r=0.54，p<0.05）。提示主动脉压力感受器可能在心率控制中起主导作用。
