Liu Kai, Wang Si, Wan Shixi, Zhou Yufei, Pan Pei, Wen Bo, Zhang Xin, Liao Hang, Shi Di, Shi Rufeng, Chen Xiaoping, Jangala Tulasiram
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
J Clin Hypertens (Greenwich). 2016 Jul;18(7):655-62. doi: 10.1111/jch.12726. Epub 2015 Nov 6.
The association between central pulsatile hemodynamic load, arterial stiffness, and orthostatic hypotension (OH) is unclear. The authors recruited 1099 participants from the community. Questionnaire, physical examination, and laboratory tests were performed. To assess the correlation between central pulsatile hemodynamic load, arterial stiffness, and OH, multiple logistic regression analysis was performed, and the discriminatory power was assessed by the area under the receiver operating curve. The prevalence of OH in this population was 5.6%. After adjusting for potential confounders, brachial-ankle pulse wave velocity (BaPWV) was significantly and positively correlated with OH in both the hypertension and nonhypertension groups (all P<.05), while central systolic blood pressure (CSBP) was only significantly associated with OH in the hypertension subgroup. In addition, BaPWV seemed to have a better discriminatory power than CSBP in both subgroups. BaPWV appears to be a better indicator of OH than CSBP in routine clinical practice.
中心搏动性血流动力学负荷、动脉僵硬度与体位性低血压（OH）之间的关联尚不清楚。作者从社区招募了1099名参与者。进行了问卷调查、体格检查和实验室检查。为评估中心搏动性血流动力学负荷、动脉僵硬度与OH之间的相关性，进行了多因素逻辑回归分析，并通过受试者工作特征曲线下面积评估鉴别能力。该人群中OH的患病率为5.6%。在调整潜在混杂因素后，高血压组和非高血压组的臂踝脉搏波速度（BaPWV）均与OH呈显著正相关（均P<0.05），而中心收缩压（CSBP）仅在高血压亚组中与OH显著相关。此外，在两个亚组中，BaPWV的鉴别能力似乎均优于CSBP。在常规临床实践中，BaPWV似乎是比CSBP更好的OH指标。
