Mori S
Division of Pathology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639.
Rinsho Byori. 2001 Aug;49(8):775-8.
Two type of human herpes viruses, type 4(Epstein Barr virus, EBV) and type 8(HHV8) are known to cause malignancies. Among those, EBV is the very most popular human oncovirus. It can cause malignant lymphomas of various subtypes including Burkitt's lymphoma, opportunistic lymphomas, pyothorax-associated lymphoma, nasal T/NK cell lymphoma, Hodgkin's disease and a part of diffuse large cell lymphomas. HHV8 is a new member of human oncovirus associating with primary effusion lymphoma, a part of solid lymphoma taking diffuse large or anaplastic large cell morphology, and the Castleman's tumor. Introduction of histopathologic methodologies makes the correct diagnosis of those herpes virus-associated tumors an easy routine test.
已知两种人类疱疹病毒，即4型（爱泼斯坦-巴尔病毒，EBV）和8型（HHV8）可引发恶性肿瘤。其中，EBV是最常见的人类致癌病毒。它可导致多种亚型的恶性淋巴瘤，包括伯基特淋巴瘤、机会性淋巴瘤、脓胸相关淋巴瘤、鼻T/NK细胞淋巴瘤、霍奇金病以及部分弥漫性大细胞淋巴瘤。HHV8是人类致癌病毒的新成员，与原发性渗出性淋巴瘤、部分呈弥漫性大细胞或间变性大细胞形态的实体淋巴瘤以及卡斯特曼病有关。组织病理学方法的引入使得对这些疱疹病毒相关肿瘤的正确诊断成为一项简单的常规检查。
