Lyons S F, Liebowitz D N
Department of Medicine, University of Chicago, IL 60637, USA.
Semin Oncol. 1998 Aug;25(4):461-75.
There are two families of viruses that contribute to lymphomagenesis in humans: herpesviruses and retroviruses. The two herpesviruses are the Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8). EBV is an extremely well-characterized transforming agent: nine viral proteins contribute to transformation in vitro. In contrast, in vivo, the pattern of EBV gene expression varies with different types of malignancies. EBV is associated with endemic Burkitt's lymphoma, acquired immune deficiency syndrome (AIDS)-related lymphoma, post-transplantation lymphoproliferative disease, Hodgkin's disease (HD), and rare T-cell lymphomas. We have summarized studies on the different patterns of viral gene expression and signaling in different EBV-related malignancies, which have begun to reveal how EBV variably contributes to the malignant phenotype in different diseases. HHV-8 is associated with primary effusion lymphomas in patients with AIDS, and the rapidly accumulating information on this virus is summarized. Human T-cell leukemia virus-1 (HTLV-1) is a retrovirus which is the causative agent of adult T-cell leukemia/lymphoma (ATL). The specific mechanism of HTLV-1-mediated T-cell transformation is unclear, but the effects of HTLV-1 on interleukin-2 signaling are reviewed.
疱疹病毒和逆转录病毒。两种疱疹病毒分别是爱泼斯坦-巴尔病毒（EBV）和人类疱疹病毒8型（HHV-8）。EBV是一种特征极为明确的转化因子：有九种病毒蛋白在体外参与转化过程。相比之下，在体内，EBV基因表达模式因不同类型的恶性肿瘤而异。EBV与地方性伯基特淋巴瘤、获得性免疫缺陷综合征（AIDS）相关淋巴瘤、移植后淋巴细胞增生性疾病、霍奇金病（HD）以及罕见的T细胞淋巴瘤有关。我们总结了关于不同EBV相关恶性肿瘤中病毒基因表达和信号传导不同模式的研究，这些研究已开始揭示EBV如何在不同疾病中以不同方式促成恶性表型。HHV-8与AIDS患者的原发性渗出性淋巴瘤有关，本文总结了关于该病毒的快速积累的信息。人类T细胞白血病病毒1型（HTLV-1）是一种逆转录病毒，是成人T细胞白血病/淋巴瘤（ATL）的病原体。HTLV-1介导T细胞转化的具体机制尚不清楚，但本文对HTLV-1对白介素-2信号传导的影响进行了综述。
