Lerou J G, Booij L H
Institute for Anaesthesiology, University of Nijmegen, The Netherlands.
Br J Anaesth. 2001 Jan;86(1):29-37. doi: 10.1093/bja/86.1.29.
We explored our model by displaying its new capabilities, testing its sensitivity to variations in input data and illustrating its use. Its multiple-gas character allows simulation of the mechanisms governing concentration and second gas effects. Simulating the volume of a standing bellows makes it possible to test algorithms for automated closed-circuit anaesthesia. Using desflurane, the model's sensitivity to changes in blood/gas partition coefficient (range 0.42-0.576), cardiac output and minute ventilation was analysed. The model was very sensitive to changes in blood solubility; other results agreed with those reported previously. An alveolar isoflurane tension of 1% atm was rapidly attained and maintained, even using 0.5 litres min(-1) of fresh gas, when isoflurane was 'co-administered' through a vaporizer set to 3.5 vol% and a single aliquot (1.25 ml liquid) injected into the expiratory limb. As a result of its credibility and capabilities, the model is to be tested in the clinical setting.
我们通过展示其新功能、测试其对输入数据变化的敏感性并说明其用途来探索我们的模型。其多气体特性允许模拟控制浓度和第二气体效应的机制。模拟直立波纹管的体积使得测试自动闭环麻醉算法成为可能。使用地氟醚，分析了模型对血/气分配系数（范围为0.42 - 0.576）、心输出量和分钟通气量变化的敏感性。该模型对血液溶解度变化非常敏感；其他结果与先前报道的一致。当异氟醚通过设置为3.5 vol%的蒸发器“共同给药”并向呼气支路注入单次等分试样（1.25 ml液体）时，即使使用0.5升/分钟的新鲜气体，也能迅速达到并维持1% atm的肺泡异氟醚张力。由于其可信度和功能，该模型将在临床环境中进行测试。
