Walker T J, Chakrabarti M K, Lockwood G G
Department of Anaesthesia, Hammersmith Hospital, London.
Anaesthesia. 1996 Jan;51(1):33-36. doi: 10.1111/j.1365-2044.1996.tb07650.x.
The amount of desflurane required to maintain an end-expired concentration of 8% was measured in 30 ASA 1 and 2 patients undergoing elective spinal surgery. The anaesthetic was administered using a computer-controlled closed circle system. After an initial period during which the expired concentration of desflurane was stabilised (4 min) the rate of uptake showed a bi-exponential decline. Mean cumulative usage of desflurane was 10.1 ml of liquid at 30 min, 14.8 ml at 60 min, 25.4 ml at 120 min, 35.8 at 180 min.
在30例接受择期脊柱手术的美国麻醉医师协会（ASA）1级和2级患者中，测量维持呼气末浓度为8%所需的地氟烷量。使用计算机控制的闭环系统给予麻醉。在最初使地氟烷呼气浓度稳定的阶段（4分钟）之后，摄取率呈双指数下降。地氟烷的平均累积用量在30分钟时为10.1毫升液体，60分钟时为14.8毫升，120分钟时为25.4毫升，180分钟时为35.8毫升。
