鞘内注射咪达唑仑可增强布比卡因脊髓阻滞对痔切除术患者的镇痛效果。
Intrathecal midazolam increases the analgesic effects of spinal blockade with bupivacaine in patients undergoing haemorrhoidectomy.
作者信息
Kim M H, Lee Y M
机构信息
Department of Anaesthesiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Br J Anaesth. 2001 Jan;86(1):77-9. doi: 10.1093/bja/86.1.77.
In the present double-blind study we aimed to evaluate the postoperative analgesic effects of intrathecal midazolam with bupivacaine following haemorrhoidectomy. Forty-five patients were randomly allocated to one of three groups: the control group received 1 ml of 0.5% heavy bupivacaine plus 0.2 ml of 0.9% saline intrathecally, group BM1 received 1 ml of 0.5% bupivacaine plus 0.2 ml of 0.5% preservative-free midazolam and group BM2 received 1 ml of 0.5% bupivacaine plus 0.4 ml of 0.5% midazolam. Time to first analgesia was significantly greater in the midazolam groups than in the placebo and significantly less in the BM1 group than in the BM2 group.
在本双盲研究中，我们旨在评估痔疮切除术后鞘内注射咪达唑仑联合布比卡因的术后镇痛效果。45例患者被随机分为三组：对照组鞘内注射1 ml 0.5%重比重布比卡因加0.2 ml 0.9%生理盐水，BM1组鞘内注射1 ml 0.5%布比卡因加0.2 ml 0.5%无防腐剂咪达唑仑，BM2组鞘内注射1 ml 0.5%布比卡因加0.4 ml 0.5%咪达唑仑。咪达唑仑组首次镇痛时间明显长于安慰剂组，且BM1组明显短于BM2组。
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