Arpino C, Domizio S, Carrieri M P, Brescianini D S, Sabatino M G, Curatolo P
E. Litta Rehabilitation Center for Developmental Disabilities, Grottaferrata, Italy.
J Child Neurol. 2001 Sep;16(9):651-6. doi: 10.1177/088307380101600905.
To evaluate prenatal and perinatal risk factors for early neonatal seizures, we conducted a case-control study including 100 newborns with neonatal seizures in the first week of life and 204 controls randomly selected from a list of healthy newborns born in the same hospital during the study period. Generalized tonic seizures were the most common seizures observed (29%), although the majority of newborns (71%) experienced more than one type of seizure. The most frequent presumed etiology of neonatal seizures was hypoxic-ischemic encephalopathy (30%). A history of epilepsy in first-degree relatives was found only for cases. Neonatal seizures were found to be associated with maternal disease in the 2 years before pregnancy, mother's weight gain > 14 kg during pregnancy, placental pathology, preeclampsia, low birthweight, low gestational age, and jaundice in the first 3 days of life. The need for cardiopulmonary resuscitation was found only for cases (37%). The causal pathways for neonatal seizures often begin before birth, and some of the factors identified may be preventable.
为评估早期新生儿惊厥的产前和围产期危险因素，我们开展了一项病例对照研究，纳入了100例出生后第一周内出现新生儿惊厥的新生儿，以及从研究期间在同一家医院出生的健康新生儿名单中随机选取的204例对照。观察到的最常见惊厥类型为全身性强直发作（29%），不过大多数新生儿（71%）经历了不止一种类型的惊厥。新生儿惊厥最常见的推测病因是缺氧缺血性脑病（30%）。仅在病例组中发现一级亲属有癫痫病史。发现新生儿惊厥与妊娠前2年的母体疾病、孕期母亲体重增加>14 kg、胎盘病理、先兆子痫、低出生体重、低胎龄以及出生后前3天出现黄疸有关。仅在病例组中发现有进行心肺复苏的需求（37%）。新生儿惊厥的因果途径通常在出生前就已开始，并且所确定的一些因素可能是可预防的。
