Delayed effect of prenatal exposure to hypoxia on the susceptibility of rats to electric seizures.

作者信息

Kalinina D S, Frolova E V, Lavrentyeva V V, Dubrovskaya N M, Lukomskaya N Ya, Kim K Kh, Zaitsev A V, Zhuravin I A, Magazanik L G

机构信息

Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia.

出版信息

Dokl Biol Sci. 2015 Nov;465(1):271-3. doi: 10.1134/S0012496615060071. Epub 2016 Jan 5.

We studied the delayed effects of prenatal exposure to hypoxia on the susceptibility of rats to seizures. The later was estimated using graded electroshock. The experiments were performed in two groups of 1.5-year-old male Wistar rats. The experimental group consisted of the animals that were exposed to hypoxia on day 14 of prenatal development, and the control group consisted of the animals that developed under the normal conditions. In the rats subjected to prenatal hypoxia, seizure episodes induced by weak currents in the range of 10-40 mA and their average duration were more pronounced as compared to the control animals.