Uddin M J, Kokubo S, Ueda K, Suenaga K, Uemura D
Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan.
J Nat Prod. 2001 Sep;64(9):1169-73. doi: 10.1021/np010066n.
Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.
从一种海鞘Lissoclinum sp.中分离出了四种新的单氯化二萜生物碱，即波照间酰胺F - I（1 - 4），以及两种已知的生物碱，二氯利斯托酰胺和氯利斯托酰胺。通过化学和光谱分析阐明了它们具有绝对立体化学结构的结构。波照间酰胺F - I（1 - 4）抑制海胆受精卵的第一次卵裂，并对P388细胞表现出强至弱的细胞毒性。
