Uddin Jasim, Ueda Katsuhiro, Siwu Eric R O, Kita Masaki, Uemura Daisuke
Department of Chemistry, Biology and Marine Sciences, University of the Ryukyus, Nishihara-cho, Okinawa 903-0213, Japan.
Bioorg Med Chem. 2006 Oct 15;14(20):6954-61. doi: 10.1016/j.bmc.2006.06.043. Epub 2006 Jul 18.
Four labdane alkaloids, haterumaimides N-Q (1-4), were isolated from an ascidian Lissoclinum sp. and their structures were elucidated by chemical and spectral analyses. Investigation of the structure-activity relationships of haterumaimides J-K, N-Q, and 14 related compounds suggested that the presence of hydroxyl groups at C-6, C-7, C-12, and C-18, a chlorine atom at C-2, and an imido NH in ring C should be essential for cytotoxicity against P388 cells.
从一种海鞘Lissoclinum sp.中分离出四种半日花烷生物碱，haterumaimides N-Q（1-4），并通过化学和光谱分析阐明了它们的结构。对haterumaimides J-K、N-Q以及14种相关化合物的构效关系研究表明，C-6、C-7、C-12和C-18位上存在羟基、C-2位上有一个氯原子以及环C上有一个亚氨基NH对于对P388细胞的细胞毒性至关重要。
