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本文引用的文献

1
Identification of transient glycosylation alterations of sialylated mucin oligosaccharides during infection by the rat intestinal parasite Nippostrongylus brasiliensis.感染巴西日圆线虫的大鼠肠道寄生虫期间，唾液酸化粘蛋白寡糖的瞬时糖基化改变的鉴定。
Biochem J. 2000 Sep 15;350 Pt 3(Pt 3):805-14.
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Measurement of sulfate in mucins.
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Pathways of O-glycan biosynthesis in cancer cells.癌细胞中O-聚糖生物合成途径。
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Endothelial ligands for L-selectin: from lymphocyte recirculation to allograft rejection.L-选择素的内皮配体：从淋巴细胞再循环到同种异体移植排斥反应
Am J Pathol. 1999 Oct;155(4):1013-20. doi: 10.1016/S0002-9440(10)65201-7.
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Separate oligosaccharide determinants mediate interactions of the low-molecular-weight salivary mucin with neutrophils and bacteria.不同的寡糖决定簇介导低分子量唾液粘蛋白与中性粒细胞和细菌的相互作用。
Biochemistry. 1999 May 25;38(21):6817-25. doi: 10.1021/bi990145m.
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Studies on the "insoluble" glycoprotein complex from human colon. Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage.关于人结肠“不溶性”糖蛋白复合物的研究。还原不敏感的MUC2寡聚体的鉴定及C末端裂解
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Permanent exposure of mucin-secreting HT-29 cells to benzyl-N-acetyl-alpha-D-galactosaminide induces abnormal O-glycosylation of mucins and inhibits constitutive and stimulated MUC5AC secretion.将分泌粘蛋白的HT-29细胞长期暴露于苄基-N-乙酰-α-D-半乳糖胺会诱导粘蛋白异常O-糖基化，并抑制组成型和刺激型MUC5AC分泌。
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Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.人低分子量唾液粘蛋白表达唾液酸化路易斯x决定簇并具有L-选择素配体活性。
Biochemistry. 1998 Apr 7;37(14):4916-27. doi: 10.1021/bi972612a.
10
Sulfated lewis X determinants as a major structural motif in glycans from LS174T-HM7 human colon carcinoma mucin.硫酸化路易斯X决定簇作为LS174T-HM7人结肠癌粘蛋白聚糖中的主要结构基序。
J Biol Chem. 1997 Dec 19;272(51):31957-68. doi: 10.1074/jbc.272.51.31957.

核心3上携带的Sd(a)抗原样结构是正常人降结肠粘蛋白聚糖的显著特征。

Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon.

作者信息

Capon C, Maes E, Michalski J C, Leffler H, Kim Y S

机构信息

Laboratoire de Glycobiologie structurale et fonctionnelle, Unité Mixte du Centre National de la Recherche Scientifique, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq Cedex, France.

出版信息

Biochem J. 2001 Sep 15;358(Pt 3):657-64. doi: 10.1042/bj3580657.

DOI:10.1042/bj3580657
PMID:11577689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1222115/
Abstract

This paper describes structural characterization by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAcbeta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.

摘要

本文描述了对尸检时新鲜获取的正常人降结肠粘蛋白聚糖进行核磁共振（NMR）、质谱（MS）结构表征及降解研究。糖类主要基于核心3（β1-3连接的N-乙酰葡糖胺和N-乙酰半乳糖胺）。在末端糖类决定簇中，Sd(a)/Cad抗原样结构显著，而Lewis x、唾液酸化Lewis x和硫酸化Lewis x为次要成分，血型H和A抗原决定簇不存在。这些糖类与迄今为止分析的结肠癌或结肠癌细胞系粘蛋白中的糖类明显不同，后者的主要特征是核心1和核心2，且发现了各种其他末端决定簇，但没有Sd(a)/Cad。