Nutting E F, Mueller M R
Fertil Steril. 1975 Aug;26(8):838-44. doi: 10.1016/s0015-0282(16)41301-4.
Copper wire intrauterine devices (CuIUD) were surgically inserted into mature female rabbits 15 days prior to artificial insemination. Gold wire intrauterine devices and sham surgery served as controls. Animals were autopsied 48, 72, 96, 120, 144, and 192 hours after artificial insemination. At autopsies performed 48 to 144 hours after insemination, the reproductive tract was flushed and the embryos were examined. At 192 hours, implantation sites were counted and measured. A significant (P less than 0.05) loss of copper from the devices was observed when the devices were weighed after autopsy. The CuIUD had no effect on ovulation, fertilization, or embryo transport up to 120 hours after artificial insemination. The presence of a CuIUD resulted in a slight, but not statistically significant, increase in embryonic degeneration by 120 hours, almost total absence of blastocysts from the uterus by 144 hours, and complete absence of implantation sites 192 hours after insemination. The antifertility effect of a copper intrauterine device appears to occur in the late preimplantation stage of pregnancy in the rabbit.
在人工授精前15天，将铜丝宫内节育器（CuIUD）手术植入成年雌性兔体内。金丝宫内节育器和假手术作为对照。在人工授精后48、72、96、120、144和192小时对动物进行尸检。在授精后48至144小时进行尸检时，冲洗生殖道并检查胚胎。在192小时时，计数并测量着床部位。尸检后称重器械时，观察到器械中有大量（P小于0.05）的铜流失。在人工授精后长达120小时，CuIUD对排卵、受精或胚胎运输没有影响。到120小时时，CuIUD的存在导致胚胎退化略有增加，但无统计学意义；到144小时时，子宫内几乎完全没有囊胚；到授精后192小时时，完全没有着床部位。铜宫内节育器的抗生育作用似乎发生在兔妊娠的着床前晚期。
