Johansson S G, Deuschl H, Zetterström O
Int Arch Allergy Appl Immunol. 1979;60(4):447-60. doi: 10.1159/000232376.
12 patients suffering from grass pollen hay fever were treated for 14 weeks pre- and co-seasonally by intranasal self-administration of an aqueous solution of a glutaraldehyde-treated timothy grass pollen allergen. These patients had a statistically significant decrease in nasal symptom scores during the grass pollen peak period and in nasal challenge end-point titre after the season compared to placebo-treated patients. No significant effect was seen on the eye symptoms. 1 patient withdrew from the trial as a consequence of too strong local nasal reactions during treatment. Most other patients treated with active material reported mild local reactions during the first minutes after administration of the nasal spray. In the actively treated group a significant increase in serum and nasal secretion of grass pollen specific IgE, IgG and IgA antibodies was obtained during the treatment. In contrast, in the placebo group a significant increase in IgE antibody levels in serum and secretion occurred during the pollen season. The reduction in symptoms and increase in antibody production together with the simplicity of the procedure makes this approach to immunotherapy attractive.
12名患有禾本科花粉过敏性鼻炎的患者在花粉季前和花粉季期间，通过鼻内自行给药戊二醛处理的梯牧草花粉变应原水溶液，接受了为期14周的治疗。与接受安慰剂治疗的患者相比，这些患者在禾本科花粉高峰期的鼻部症状评分以及花粉季后的鼻激发终点滴度均有统计学意义的下降。对眼部症状未观察到显著影响。1名患者因治疗期间鼻部局部反应过强退出试验。大多数接受活性物质治疗的其他患者在喷鼻后最初几分钟报告有轻度局部反应。在积极治疗组中，治疗期间草花粉特异性IgE、IgG和IgA抗体的血清和鼻分泌物显著增加。相比之下，在安慰剂组中，花粉季期间血清和分泌物中的IgE抗体水平显著增加。症状减轻、抗体产生增加以及操作简便使得这种免疫疗法具有吸引力。
