Capogrosso Sansone B, Scalerandi M, Condat C A
INFM, Dipartimento di Fisica, Politecnico di Torino, Torino, Italy.
Phys Rev Lett. 2001 Sep 17;87(12):128102. doi: 10.1103/PhysRevLett.87.128102. Epub 2001 Sep 4.
Angiogenesis, the expansion of the vascular system feeding a tumor, is crucial to both primary tumors long-time growth and for the successful implantation of metastases. We formulate a model that relates the energetic requirements of the cancer cells to the production and diffusion of an angiogenic factor and to the ensuing evolution of neighboring endothelial cells. The model yields predictions for the development of neovascularization and for the increase in the blood flow to the tumor. We show that the directed growth of the vascular net is an emergent property and that therapies targeting different stages of the angiogenic process might have a synergistic effect.
血管生成，即供养肿瘤的血管系统的扩张，对于原发性肿瘤的长期生长以及转移灶的成功植入都至关重要。我们构建了一个模型，该模型将癌细胞的能量需求与血管生成因子的产生、扩散以及相邻内皮细胞的后续演变联系起来。该模型对新血管形成的发展以及肿瘤血流量的增加给出了预测。我们表明血管网络的定向生长是一种涌现特性，并且针对血管生成过程不同阶段的治疗可能具有协同作用。
