Goto K, Kurokawa Y, Hayashi J, Sato H
Gan. 1975 Feb;66(1):89-93.
Two transplantable strains of adenocarcinoma were established from the carcinomas of the colon and rectum induced by infusion of N-methyl-N'-nitro-N-nitrosoguanidine in inbred ACI/N rats, The tumors are solid type, not converted to ascite form yet, either papillary or tubulo-papillary adenocarcinomas, and particularly grow slowly, showing 2 to 4 months of survival in animals transplanted subcutaneously. Besides histological resemblance of the tumors to human adenocarcinoma of the large intestine, marked mucin production in tumor was noted in one of these strains.
通过向近交系ACI/N大鼠输注N-甲基-N'-硝基-N-亚硝基胍诱导结肠和直肠癌，建立了两种可移植的腺癌株。这些肿瘤为实体型，尚未转化为腹水型，为乳头状或管状乳头状腺癌，生长特别缓慢，皮下移植的动物存活2至4个月。除了肿瘤在组织学上与人类大肠腺癌相似外，在其中一个株系中还发现肿瘤中有大量粘蛋白产生。
