Narisawa T, Wong C Q, Weisburger J H
Gan. 1976 Feb;67(1):41-6.
Intrarectal instillation of 0.5 ml of a 0.125% solution of N-methyl-N'-nitro-N-nitrosoguanidine twice weekly for 53 weeks to female inbred strain-2 guinea pigs induced multiple large bowel adenocarcinomas in 13 of 15 animals in 52 to 85 weeks. The lesions were plaque-shaped in small tumors and infiltrative or constrictive in large advanced tumors. The neoplasms showed histological features in varied grades of differentiation and invasiveness similar to those of human cases. These findings distinquished them from large bowel cancers chemically induced in rats and mice.
每周两次向雌性近交系2豚鼠直肠内注入0.5毫升0.125%的N-甲基-N'-硝基-N-亚硝基胍溶液，持续53周，在52至85周时，15只动物中有13只诱发了多发性大肠腺癌。小肿瘤的病变呈斑块状，大的晚期肿瘤呈浸润性或缩窄性。这些肿瘤表现出不同分化程度和侵袭性的组织学特征，与人类病例相似。这些发现使它们有别于化学诱导的大鼠和小鼠大肠癌。
