脱氧胆酸钠对无菌大鼠结肠腺癌的促进作用。
Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats.
作者信息
Reddy B S, Narasawa T, Weisburger J H, Wynder E L
出版信息
J Natl Cancer Inst. 1976 Feb;56(2):441-2. doi: 10.1093/jnci/56.2.441.
The promoting effect of sodium deoxycholate (DC) on colon carcinogenesis was studied in female F344 germfree rats. Animals received intrarectal (ir) instillations of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 4 weeks (total dose, 16 mg/rat), then weekly ir doses of DC (total dose, 3 g/rat); the rats were autopsied 52 weeks after the first injection. DC increased the number of MNNG-induced colon adenocarcinomas. No tumors were in the colons of germfree rats given DC alone. It was concluded that DC (present in high concentrations in human stools) had a promoting effect on colon carcinogenesis in rats.
在雌性F344无菌大鼠中研究了脱氧胆酸钠（DC）对结肠癌发生的促进作用。动物经直肠内（ir）注入N-甲基-N'-硝基-N-亚硝基胍（MNNG）4周（总剂量，16mg/只大鼠），然后每周经直肠内给予DC（总剂量，3g/只大鼠）；在首次注射后52周对大鼠进行尸检。DC增加了MNNG诱导的结肠腺癌数量。单独给予DC的无菌大鼠结肠中未出现肿瘤。得出的结论是，DC（在人类粪便中高浓度存在）对大鼠结肠癌发生具有促进作用。
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